Senior Scientist, Immunology

Work at the cutting-edge, where scientific innovations and an entrepreneurial spirit are the norm.

And in return… we’re looking for curious minds, comfortable taking smart risks and learning from failures.

We work independently or in partnerships to deliver the next wave of science and address unmet medical needs.

This is the place to make an impact. Here we ensure everyone can reach their full potential, perform at their best and make a valued contribution to the enterprise.

Are you a passionate Scientist striving to make a true impact on patients’ lives? The vision of AstraZeneca Early Respiratory & Immunology is centered on delivering life-changing therapies that advance world health and help fight and cure disease. Here, you’ll have the opportunity to make a difference in people’s lives every day. Are you ready to join us and see what science can do?

At AstraZeneca, we believe in the potential of our people and you’ll develop beyond what you thought possible. We make the most of your skills and passion by actively supporting you to see what you can achieve no matter where you start with us!

We are seeking a highly motivated Senior Scientistresearcher to join the BioscienceAsthma & Skin Immunity research group in Cambridge, UK to work on research projects focused on investigating the pathogenesis of skin diseases including atopic dermatitis, and the identification of novel targets. Within our Cambridge based research team, we are seeking an experienced research scientist with a strong understanding of T cell immunology and experience with primary immune cells. In this role, you would be expected to demonstrate an exceptionally high level of enthusiasm for innovative scientific research leading to the discovery and development of novel therapeutics. Ideally, you have strong expertise in T cell biology, and strong background in immunology with the ability to apply this experience to an understanding of the basic mechanisms of human skin pathologies.

What you’ll do:

This job is a lab-based research role, and you will have a significant opportunity to drive the direction of the work. The work will be predominantly human in vitro systems and working with primary and disease tissue-derived cells. A background in human skin diseases and translational approaches to understand basic biological mechanisms in disease is desirable.

• You will focus your research on characterizing novel biology pathways in skin diseases to aid target validation and drug projects.

• The role will be based in Cambridge within AstraZeneca’s state-of-the-art laboratories where you will follow the science to help drive innovation and advance medicine to help improve patient lives.

• You will collaborate with scientists from a variety of functional teams in Cambridge and with our sites in Gaithersburg, US and Gothenburg, Sweden.

• You will benefit from daily interaction and collaboration with highly accomplished scientists and the position offers a unique opportunity to work in a dynamic and innovative environment developing your career at the interface of research and drug discovery.

• You will have the opportunity to mentor junior scientists

• Encouragement and support will be provided to help you develop specialist knowledge and skillsets.

• Publication of your work in high impact journals.

Essential for the role:

• A Ph.D. and Postdoc in Immunology with major focus in T cell responses or skin immunology

• In vitro culture, differentiation and functional assays of T cell, monocyte-derived dendritic cells

• Processing of human tissue samples (eg. skin biopsy processing, epidermal and dermal separation, peripheral blood mononuclear cell isolation)

• Functional in vitro assays (co-culture experiments, MSD multiplex cytokines, screening of compounds)

• Strong hands-on skills in basic biochemical and molecular techniques including cell culture, quantification of mRNA (qPCR) and protein expression; ELISA, Western blot, Immunohistochemistry and flow cytometry.

• Highly organized and self-motivated, with the ability to work independently as well as collaboratively within a team to conduct a high-level research project.

• Strong written and oral communication skills and the ability to critically analyse data sets.

• Demonstrated ability to run collaborative efforts and utilize external resources to find the most effective solutions to deliver high-quality science, translatable to human disease.

• Excellent publication record (project is expected to yield publication of scientific results in peer-reviewed journals) and the ability to apply current scientific literature to projects.

At AstraZeneca, we ’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.

We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or
interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Are you already imagining yourself joining us? Good, because we can’t wait to hear from you!