Postdoctoral Scientist

To work within the group of Dr Ramanujan Hegde at the Laboratory of Molecular Biology (LMB), within a programme aimed at understanding the molecular mechanisms of protein maturation, quality control, and protein aggregation diseases. Specifically, to undertake research to investigate the mechanistic basis of membrane protein insertion and assembly.

Main duties:

• To undertake research aimed at understanding the molecular mechanisms of membrane protein insertion and assembly.
• To identify, develop and apply a broad range of techniques to pursue the research objectives.
• To present scientific work at seminars within the laboratory and at external meetings.
• To contribute to laboratory-wide discussions on developments within the field.
• To draft scientific papers, and contribute to the overall preparation of research for publication.
• To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.
• To assist in the training of PhD students and other members of the LMB.

Key responsibilities:

Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a 3-year year lifespan.

To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor.

To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

To enhance your research and generic skills through a tailored development programme.

Working relationships:

You will report to Dr Ramanujan Hegde and will interact and collaborate with other Postdoctoral Scientists, Research Support staff and students, not only in your group, but also across the LMB and with external groups as necessary.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.

Academic qualifications:

These should include a PhD in a relevant subject or due to complete PhD within 6 months.

For the envisioned project, relevant subjects for a PhD should include cell biology, particularly in the area of organelle biology.

Technical skills and expertise:

Essential
Experience of and ability to perform techniques relevant to the project, essential skills would be:

A high level of proficiency in ability to work with membranes.

Experience with mammalian cell culture, analysis of cellular organelles, and genetic manipulation of mammalian cells.

Deep knowledge of the biology of the endoplasmic reticulum.

Experience in core methods of cell biology in biochemistry including: microscopy, flow cytometry, protein analysis, basic biochemistry, protein purification, and molecular biology.

Desirable
Experience and knowledge of biological processes occurring at membranes.

Experience in organelle biology and homeostasis.

Experience in applying multiple methods to solve a problem.

Experience in cellular stress responses and quality control.

Track record of research:

This will include achievements, and contributions to published papers of high impact.

Other relevant evidence of:

• Commitment.
• Originality.
• Ability to communicate.
• Working with others.