Senior Scientist, LCMS

Job content

The Role:
Joining Moderna offers the unique opportunity to be part of a pioneering team that’s revolutionizing medicine through mRNA technology with a diverse pipeline of development programs across various diseases. As an employee, you’ll be part of a continually growing organization working alongside exceptional colleagues and strategic partners worldwide, contributing to global health initiatives. Moderna’s commitment to advancing the technological frontier of mRNA medicines ensures a challenging and rewarding career experience with the potential to make a significant impact on patients’ lives worldwide.

Moderna’s strategic partnership with the UK Government is exemplified by our innovative presence at Harwell. Our mission is to establish a leading-edge research, development, and manufacturing facility as part of a long-term commitment to onshore mRNA vaccine production for respiratory diseases. This initiative will create a multitude of highly skilled jobs and foster collaboration with academic and NHS partners across the UK. We’re looking for global experts eager to join us in this endeavor, contributing to a future where access to life-saving vaccines is a reality for all​​.

Moderna’s Bioanalytical and Molecular Assay team is looking for a Senior Scientist with strong hands-on experience in the regulated bioanalytical LC-MS/MS area. The individual should have recent experiences in processing and analysis of a wide range of molecules such as lipids, proteins, peptides, oligos, etc. The role will support method development for the clinical development of candidates applying cutting-edge LC/MS techniques toward mechanistic and quantitative assessment of Moderna’s mRNA therapeutics. The candidate must thrive in a scientifically stimulating, fast-paced environment with high expectations. Independent method development, validation, the ability to troubleshoot, collaborate with cross-functional teams, respect for peers/colleagues, excellent work ethic, and setting the bar high are key values to thrive in our team.

Here’s What You’ll Do:Your key responsibilities will be:
Leading regulated bioanalytical projects of method development, validation, and sample analysis to support various Moderna Clinical Programs.

Developing, qualifying, and/or validating LC/MS methods for the quantitation of various types of biomolecules, mainly lipids, but also proteins (peptides), amino acids, and oligos.

Evaluating and reviewing raw data, assay validation reports, sample analysis reports, as appropriate, to ensure laboratories are performing analysis in compliance with current regulatory, industry, and Moderna standards and that data are of the required quality (regulatory and scientific).

Supporting nonclinical studies to evaluate PK/TK, safety, and efficacy of Moderna’s drug candidates.

Overseeing external CROs on method development and validation.

Your responsibilities will also include:
Performing method transfer to internal and external stakeholders for qualification/validation.

Reviewing and authoring SOPs, relevant protocols, and reports and interacting with QAs.

Working closely with colleagues in the clinical development organization as well as other cross-functional groups.

Mentoring and training junior members of the group.

The key Moderna Mindsets you’ll need to succeed in the role:
Pursue options in parallel : Effectively managing multiple tasks and projects to ensure the best outcomes through a comprehensive approach.

Dynamic range : Demonstrating the capacity to drive both strategy and execution, adapting swiftly to new data and changing priorities.

Here’s What You’ll Bring to the Table:
Ph.D. with least 7+ years or MS with 10+ years of demonstrated hands-on experience with the development and validation of bioanalytical methods using LC-MS

Hands-on experience with the development of sample preparation/extraction techniques for various analytes from biological matrices such as SPE, LLE, protein precipitation, IP-LCMS/MS

In-depth knowledge of US and EU regulations and ICH guidelines. Assist in writing regulatory submissions and in responding to regulatory queries when needed.

Experience with metabolite profiling, identification, and characterization of metabolites using High-resolution mass spectrometry (HRMS) – Met ID of small molecules and lipids are preferred

Ability to develop and implement methods for high throughput or (semi-)automated data analysis

Willingness to learn new concepts and challenge boundaries; adaptability to change

Organization and attention to detail; ability to handle multiple projects in a fast-paced environment

Strong interpersonal skills with an eagerness to work with and support colleagues in other departments

Proven ability to develop and work independently and to collaborate cross-functionally to accomplish goals in a timely manner

CROs management experience is preferred

GLP and or GCP experience

Moderna offers personalized benefit programs and well-being resources as unique as our global workforce so employees can do their best work.

We recognize and appreciate your diverse needs and interests and do our best to support you at work and at home with:
Quality healthcare and insurance benefits
Lifestyle Spending Accounts to create your own pathway to well-being
Free premium access to fitness, nutrition, and mindfulness classes
Family planning and adoption benefits
Generous paid time off, including vacation, bank holidays, volunteer days, sabbatical, and a discretionary year-end shutdown
Educational resources
Savings and investments
Location-specific perks and extras!

The benefits offered may vary depending on the nature of your employment with Moderna and the country where you work.

About Moderna
Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit modernatx.com/careers to learn more about our current opportunities.

Moderna is a smoke-free, alcohol-free and drug-free work environment.

Moderna is a place where everyone can grow. If you meet the Basic Qualifications for the role and you would be excited to contribute to our mission every day, please apply!

Moderna is proud to be an equal opportunity workplace and is an affirmative action employer.

Moderna is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, sex, gender identity or expression, age, religion, national origin, ancestry or citizenship, ethnicity, disability, military or protected veteran status, genetic information, sexual orientation, marital or familial status, or any other personal characteristic protected under applicable law. Moderna is an E-Verify Employer in the United States. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements.

Belonging, Inclusion, and Diversity are critical to the success of our company and our impact on society. We’re focused on attracting, retaining, developing, and advancing our employees and believe that by cultivating diverse experiences, backgrounds, and ideas, we can provide an environment where every employee is able to contribute their best.

Moderna is committed to offering reasonable accommodations to qualified job applicants with disabilities. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the Talent Acquisition Partner or contact the Accommodations team at leavesandaccommodations@modernatx.com . (EEO/AAP Employer) #LI-NS1
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